Systematic reviews have gained momentum as a key method of evidence synthesis in global development research in recent times. As defined in the Cochrane Handbook on Systematic reviews “Systematic reviews seek to collate evidence that fits pre-specified eligibility criteria in order to answer a specific research question. They aim to minimize bias by using explicit, systematic methods documented in advance with a protocol.” This document provides guidelines and recommendations for conducting mixed- method systematic reviews for evidence synthesis for “gender in agriculture and food systems” for the CGIAR GENDER Platform. It includes best practices from existing literature and recommends steps to adapt these practices in the context of CGIAR’s work.